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Tirzepatide

Catalog No.

TP1111

Purity:

99.99%

⭐️⭐️⭐️⭐️⭐️

HOT
Tirzepatide (LY-3298176) is a dual agonist of glucose-dependent polypeptide (GIP) (EC50=0.042 nM) and glucagon-like peptide-1 (GLP-1) (EC50=0.086 nM) receptors, and it has neuroprotective activity. It can improve blood pressure and lower low-density lipoprotein (LDL) cholesterol and triglycerides, and can be used to study diabetes and obesity.
Tirzepatide - Image 1
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Price range: $56.00 through $287.00

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Tirzepatide Common Questions

What’s pIC50?

pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).

What’s Kd?

Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.

Product Introduction

Bioactivity

Description

Tirzepatide (LY-3298176) is a dual agonist of glucose-dependent polypeptide (GIP) (EC50=0.042 nM) and glucagon-like peptide-1 (GLP-1) (EC50=0.086 nM) receptors, and it has neuroprotective activity. It can improve blood pressure and lower low-density lipoprotein (LDL) cholesterol and triglycerides, and can be used to study diabetes and obesity.

Targets & IC50

ERG current (human):> 300 µM

In vitro

METHODS: SHSY5Y cells were treated with Tirzepatide (0-0.4 μM) for 7 days, and the expression level of target proteins was detected by Western Blot method.
RESULTS: Tirzepatide upregulates the protein levels of CREB and BDNF, and simultaneously increases the protein levels of Bcl-2, pAkt, MAP2, GAP43, AGBL4, GLUT4, and SORBS1. [1]

In vitro

Methods: To investigate the effect of Tirzepatide on obesity, Tirzepatide (10 nmol/kg) was administered subcutaneously to obese mice induced by high-fat diet.
Results: Treatment with Tirzepatide reduced body weight in mice and also improved obesity-induced serum adiponectin, leptin, GIP, and C-reactive protein levels. [2]

Synonyms

LY-3298176

Chemical Properties

Molecular Weight

4813.45

Formula

C225H348N48O68

Cas No.

2023788-19-2

Smiles

CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](C(=O)O)NC(=O)CCCCCCCCCCCCCCCCCCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N4CCC[C@H]4C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N5CCC[C@H]5C(=O)N6CCC[C@H]6C(=O)N7CCC[C@H]7C(=O)N[C@@H](CO)C(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)C(C)(C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](CC8=CC=C(C=C8)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC9=CC=CC=C9)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@H](CC1=CC=C(C=C1)O)N

Relative Density.

no data available

Sequence

Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{C20 diacid-gamma-Glu-(Ala-Glu-Glu-Ala)2-Lys}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Sequence Short

Y-{Aib}-EGTFTSDYSI-{Aib}-LDKIAQ-{C20 diacid-gamma-Glu-(AEEA)2-Lys}-AFVQWLIAGGPSSGAPPPS

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.
Actual storage temperature shall be subject to the COA.

Formula

DMSO: 100 mg/mL (20.78 mM), Sonication is recommended. 🏅
H2O: < 0.5 mg/mL (insoluble) 🏅

Solution Preparation Table

DMSO

1mg

5mg

10mg

50mg

1 mM

0.2078 mL

1.0388 mL

2.0775 mL

10.3876 mL

5 mM

0.0416 mL

0.2078 mL

0.4155 mL

2.0775 mL

10 mM

0.0208 mL

0.1039 mL

0.2078 mL

1.0388 mL

20 mM

0.0104 mL

0.0519 mL

0.1039 mL

0.5194 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

References