LL37
LL-37 is a human antimicrobial peptide belonging to the cathelicidin family and is the only cathelicidin-derived peptide identified in humans. It plays a critical role in innate immunity, exhibiting broad-spectrum antimicrobial activity against bacteria, viruses, and fungi. In addition to its antimicrobial properties, LL-37 is involved in immune modulation, wound healing, and regulation of inflammatory responses, making it widely used in research related to host defense and tissue repair.
$140.00
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Questions
LL37 Common Questions
What’s pIC50?
pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
What’s Kd?
Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
Product Introduction
Bioactivity
Description
LL-37 is a human antimicrobial peptide belonging to the cathelicidin family and is the only cathelicidin-derived peptide identified in humans. It plays a critical role in innate immunity, exhibiting broad-spectrum antimicrobial activity against bacteria, viruses, and fungi. In addition to its antimicrobial properties, LL-37 is involved in immune modulation, wound healing, and regulation of inflammatory responses, making it widely used in research related to host defense and tissue repair.
Targets & IC50
Targets:
Bacterial Cell Membrane
Formyl Peptide Receptor 2 (FPR2)
Innate Immune Response
NF-κB Signaling Pathway
IC50:
Not applicable (LL-37 acts via membrane disruption and receptor-mediated signaling, not classical inhibition)
In vitro
METHODS: Human keratinocytes, macrophages, and bacterial cultures (e.g., E. coli, S. aureus) were treated with LL-37 (0–50 μM) for 6–48 hours. Antimicrobial activity, cytokine expression, and cell migration were evaluated using MIC assays, ELISA, and wound healing assays.
RESULTS: LL-37 exhibits broad-spectrum antimicrobial activity by disrupting microbial membranes. It modulates immune responses through interaction with receptors such as FPR2 and regulates inflammatory signaling pathways including NF-κB. Additionally, LL-37 promotes wound healing by enhancing keratinocyte migration and angiogenesis. No significant cytotoxicity is observed at controlled experimental concentrations. [1]
Synonyms
Cathelicidin LL-37
Chemical Properties
Molecular Weight
4493.3 Da
Formula
C₂₀₅H₃₄₀N₆₀O₅₃ (approximate)
Cas No.
154947-66-7
Smiles
Not applicable (peptide)
Relative Density.
Not available
Sequence
LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Sequence Short
37 aa
Storage & Solubility Information
Storage
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.