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AOD 9604

Catalog No.

T7815L

Purity:

99.99%

⭐️⭐️⭐️⭐️⭐️

HOT
AOD9604 acetate(221231-10-3 free base) is a potential anti-obesity peptide based on the human growth hormone.
AOD 9604 - Image 1
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Price range: $77.00 through $252.00

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

AOD9604 Common Questions

What’s pIC50?

Effective dose 50 (ED50）refers to the dose of a drug that produces a specific effect in 50% of the population that has been administered that dose.
What’s IC50?
Half-maximal inhibitory concentration (IC50) refers to the concentration of the inhibitor which is required to inhibit a given biological or biochemical function by half.

Product Introduction

Bioactivity

Description

AOD9604 acetate(221231-10-3 free base) is a potential anti-obesity peptide based on the human growth hormone.

Targets & IC50

ERG current (human):> 300 µM

In vitro

METHODS: 3T3-L1 adipocytes and human adipocyte cell models were treated with AOD9604 (0–10 μM) for 24–72 hours. Lipolytic activity and adipogenic markers were evaluated using glycerol release assays, Oil Red O staining, and Western blot analysis to detect the expression levels of lipid metabolism-related proteins.

RESULTS: AOD9604 significantly stimulates lipolysis in adipocytes, as evidenced by increased glycerol release. It reduces lipid accumulation and downregulates lipogenic markers while enhancing fat metabolism-related pathways. In addition, AOD9604 does not significantly affect cell proliferation or activate growth hormone-associated mitogenic signaling pathways, indicating a selective lipolytic activity profile with minimal impact on cell growth. [1]

Synonyms

AOD-9604 acetate, AOD9604 acetate, AOD 9604 acetate

Chemical Properties

Molecular Weight

1875.15

Formula

C80H127N23O25S2

Smiles

CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCNC(=N)N)CO)C(C)C)CCC(=O)O)CO)C(=O)NCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)N.CC(=O)O

Relative Density.

no data available

Sequence

H-Tyr-Leu-Arg-Ile-Val-Gln-DL-Cys(1)-Arg-DL-Ser-Val-Glu-Gly-Ser-DL-Cys(1)-Gly-Phe-OH

Sequence Short

YLRIVQCRSVEGSCGF

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.
Actual storage temperature shall be subject to the COA.

Formula

H2O: 5 mM, Sonication is recommended. 🏅
DMSO: Insoluble 🏅

Solution Preparation Table

H2O

1mg

5mg

10mg

50mg

1 mM

0.5333 mL

2.6665 mL

5.3329 mL

26.6645 mL

5 mM

0.1067 mL

0.5333 mL

1.0666 mL

5.3329 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

References