CJC-1295 With DAC
Price range: $133.00 through $255.00
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
Questions
CJC-1295 Common Questions
What’s ED50?
Product Introduction
Bioactivity
Description
In vitro
CJC-1295 markedly increases plasma growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in both animals and humans.[1] With a single injection, in human subjects, CJC-1295 increases plasma GH levels by 2- to 10-fold for 6 days or longer and plasma IGF-1 levels by 0.5- to 3-fold for 9 to 11 days.[3] The drug has an estimated half-life of about 6 to 8 days in humans.[3] With multiple doses of CJC-1295, IGF-1 levels were found to remain elevated in humans for up to 28 days
Synonyms
DAC:GRF acetate
Chemical Properties
Molecular Weight
3428.01
Formula
C154H256N44O44
Smiles
CC[C@@H]([C@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](N)CC1=CC=C(O)C=C1)=O)C)=O)CC(O)=O)=O)C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)CO)=O)CC(C)C)=O)[C@H](CC)C)=O)CC(O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CC(C)C)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CO)=O)CC(C)C)=O)CCC(N)=O)=O)C)=O)CC(C)C)=O)C(C)C)=O)CCCCN)=O)CCCNC(N)=N)=O)CC2=CC=C(O)C=C2)=O)CO)=O)CCC(N)=O)=O)[C@H](O)C)=O)CC3=CC=CC=C3)=O)C.CC(O)=O
Relative Density.
no data available
Sequence
H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2.CH3CO2H
Sequence Short
YADAIFTQSYRKVLAQLSARKLLQDILSR
Storage & Solubility Information
Storage
Formula
Solution Preparation Table
DMSO
|
1mg |
5mg |
10mg |
50mg |
|
|---|---|---|---|---|
|
1 mM |
0.2917 mL |
1.4586 mL |
2.9171 mL |
14.5857 mL |
|
5 mM |
0.0583 mL |
0.2917 mL |
0.5834 mL |
2.9171 mL |
|
10 mM |
0.0292 mL |
0.1459 mL |
0.2917 mL |
1.4586 mL |
|
20 mM |
0.0146 mL |
0.0729 mL |
0.1459 mL |
0.7293 mL |
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.
References
- 1.Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, et al. (July 2005). "Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog". Endocrinology. 146 (7): 3052–8.
- 2.Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R (December 2006). "Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse". American Journal of Physiology. Endocrinology and Metabolism. 291 (6): E1290-4
- 3.Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA (March 2006). "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults". The Journal of Clinical Endocrinology and Metabolism. 91 (3): 799–805.