CJC-1295 Without DAC
CJC-1295 Without DAC, also known as Modified Growth Hormone Releasing Factor 1-29 (Mod GRF 1-29), is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). It is engineered with amino acid substitutions to enhance stability and resistance to enzymatic degradation while maintaining a short plasma half-life compared to DAC-conjugated forms. This peptide stimulates pulsatile secretion of growth hormone (GH) by activating the growth hormone-releasing hormone receptor.
Price range: $42.00 through $126.00
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
Questions
CJC-1295 Without DAC Common Questions
What’s pIC50?
pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
What’s Kd?
Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
Product Introduction
Bioactivity
Description
CJC-1295 Without DAC, also known as Modified Growth Hormone Releasing Factor 1-29 (Mod GRF 1-29), is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). It is engineered with amino acid substitutions to enhance stability and resistance to enzymatic degradation while maintaining a short plasma half-life compared to DAC-conjugated forms. This peptide stimulates pulsatile secretion of growth hormone (GH) by activating the growth hormone-releasing hormone receptor.
Targets & IC50
Targets:
Growth Hormone-Releasing Hormone Receptor (GHRHR)
cAMP Signaling Pathway
GH/IGF-1 Axis
IC50:
Not applicable
(CJC-1295 Without DAC is a receptor agonist peptide, not an inhibitor)
In vitro
METHODS: Rat pituitary cell lines and primary anterior pituitary cells were treated with CJC-1295 Without DAC (0–100 nM) for 1–24 hours. Growth hormone secretion and downstream signaling were evaluated using ELISA assays and cAMP response measurements.
RESULTS: CJC-1295 Without DAC stimulates growth hormone secretion in a dose-dependent manner via activation of the GHRH receptor. It enhances intracellular cAMP levels and promotes pulsatile GH release. Compared to native GHRH, the modified peptide demonstrates improved stability while maintaining receptor specificity. No significant cytotoxicity is observed at commonly used experimental concentrations. [1]
Synonyms
CJC-1295 (No DAC)
Chemical Properties
Molecular Weight
~3367.9 Da
Formula
~C₁₅₂H₂₅₂N₄₄O₄₂ (approximate)
Cas No.
Not universally standardized (varies by naming and modification form)
Smiles
Not applicable (peptide)
Relative Density.
Not available
Sequence
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg
Sequence Short
29 aa
Storage & Solubility Information
Storage
Formula