PEG MGF
PEG-MGF is a pegylated form of Mechano Growth Factor (MGF), an IGF-1 splice variant involved in muscle repair and regeneration. The addition of a polyethylene glycol (PEG) moiety significantly increases peptide stability and extends its half-life compared to native MGF. PEG-MGF is widely used in research focused on tissue repair, muscle regeneration, and anabolic signaling pathways.
$119.00
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Questions
PEG MGF Common Questions
What’s pIC50?
pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
What’s Kd?
Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
Product Introduction
Bioactivity
Description
PEG-MGF is a pegylated form of Mechano Growth Factor (MGF), an IGF-1 splice variant involved in muscle repair and regeneration. The addition of a polyethylene glycol (PEG) moiety significantly increases peptide stability and extends its half-life compared to native MGF. PEG-MGF is widely used in research focused on tissue repair, muscle regeneration, and anabolic signaling pathways.
Targets & IC50
Targets:
Insulin-like Growth Factor 1 Receptor (IGF-1R)
PI3K/Akt Pathway
MAPK/ERK Pathway
IC50:
Not applicable (PEG-MGF is a peptide growth factor analog, not an inhibitory compound)
In vitro
METHODS: C2C12 myoblasts and primary skeletal muscle cells were treated with PEG-MGF (0–100 nM) for 24–96 hours. Cell proliferation, differentiation, and signaling pathway activation were evaluated using Western blot analysis, immunofluorescence, and cell viability assays.
RESULTS: PEG-MGF promotes myoblast proliferation and enhances muscle cell repair processes through activation of IGF-1 receptor-mediated signaling pathways, including PI3K/Akt and MAPK/ERK. Compared to native MGF, PEG-MGF demonstrates prolonged activity due to increased stability and reduced degradation. It supports sustained anabolic signaling and improves cellular survival without significant cytotoxicity at commonly used experimental concentrations. [1]
Synonyms
Pegylated MGF
Chemical Properties
Molecular Weight
Variable (depends on PEG size, typically 2–10 kDa PEG conjugation)
Formula
Not applicable (peptide + PEG conjugate)
Cas No.
Not standardized (varies by PEGylation and manufacturer)
Smiles
Not applicable (peptide conjugate)
Relative Density.
no data available
Sequence
MGF peptide sequence (IGF-1 Ec domain fragment) conjugated with PEG moiety
Sequence Short
24 aa (MGF core sequence, variant-dependent)
Storage & Solubility Information
Storage
Formula