HMG
HMG $98.00
Back to products
Thymosin Alpha-1
Thymosin Alpha-1 Price range: $154.00 through $252.00

B12

Catalog No.

B12

Purity:

99.99%

⭐️⭐️⭐️⭐️⭐️

HOT
Cyanocobalamin is a cobalt-containing coordination compound generated by intestinal microbes and a natural water-soluble vitamin of the B-complex family that must combine with Intrinsic Factor for absorption by the intestine. Cyanocobalamin is necessary for hematopoiesis, neural metabolism, DNA, and RNA production, and carbohydrate, fat, and protein metabolism. B12 improves iron functions in the metabolic cycle and assists folic acid in choline synthesis. B12 metabolism is interconnected with that of folic acid. Vitamin B12 (Cobalamin) deficiency causes pernicious anemia, megaloblastic anemia, and neurologic lesions.
 
B12 - Image 1
Click to enlarge

$70.00

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

B12 Common Questions

What’s pIC50?

pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).

What’s Kd?

Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.

Product Introduction

Bioactivity

Description

Cyanocobalamin is a cobalt-containing coordination compound generated by intestinal microbes and a natural water-soluble vitamin of the B-complex family that must combine with Intrinsic Factor for absorption by the intestine. Cyanocobalamin is necessary for hematopoiesis, neural metabolism, DNA, and RNA production, and carbohydrate, fat, and protein metabolism. B12 improves iron functions in the metabolic cycle and assists folic acid in choline synthesis. B12 metabolism is interconnected with that of folic acid. Vitamin B12 (Cobalamin) deficiency causes pernicious anemia, megaloblastic anemia, and neurologic lesions.

Synonyms

Cyanocobalamin

Chemical Properties

Molecular Weight

1355.37

Formula

C63H88CoN14O14P

Cas No.

68-19-9

Smiles

[Co++]C#N.[H][C@]12N=C(\C(C)=C3/N=C(/C=C4\N=C(\C(\C)=C5/[N-][C@]1(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O)[C@](C)(CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@@H]1[C@@H](CO)O[C@@H]([C@@H]1O)n1cnc3cc(C)c(C)cc13)[C@H]2CC(N)=O

Relative Density.

1.351. Temperature:20 °C.

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.
Actual storage temperature shall be subject to the COA.

Formula

Ethanol: 10 mg/mL (7.38 mM), Sonication is recommended.🏅
H2O: 6 mg/mL (4.43 mM), Sonication is recommended. 🏅
DMSO: 2.71 mg/mL (2 mM), Sonication is recommended. 🏅

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (0.74 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

References

  • 1.Ghazanfari S, et al. Drug Res (Stuttg). 2014 Mar;64(3):113-7.