HMG
Human Menopausal Gonadotropin (HMG) is a purified gonadotropin preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. It is derived from the urine of postmenopausal women and is widely used in research involving reproductive endocrinology, gonadal function, and hormone regulation. HMG plays a key role in stimulating ovarian follicular development and spermatogenesis through activation of specific gonadotropin receptors.
$98.00
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Questions
HMG Common Questions
What’s pIC50?
pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
What’s Kd?
Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
Product Introduction
Bioactivity
Description
Human Menopausal Gonadotropin (HMG) is a purified gonadotropin preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. It is derived from the urine of postmenopausal women and is widely used in research involving reproductive endocrinology, gonadal function, and hormone regulation. HMG plays a key role in stimulating ovarian follicular development and spermatogenesis through activation of specific gonadotropin receptors.
Targets & IC50
Targets:
Follicle-Stimulating Hormone Receptor (FSHR)
Luteinizing Hormone/Chorionic Gonadotropin Receptor (LHCGR)
cAMP Signaling Pathway
Steroidogenesis Pathway
IC50:
Not applicable (HMG is a hormone mixture with agonist activity, not an inhibitory compound)
In vitro
METHODS: Ovarian granulosa cells and testicular Sertoli/Leydig cell models were treated with HMG (0–100 IU/mL) for 24–72 hours. Hormone production, receptor activation, and downstream signaling were evaluated using ELISA assays, cAMP measurements, and Western blot analysis.
RESULTS: HMG stimulates gonadal cells via activation of both FSH and LH receptors, leading to increased intracellular cAMP levels and enhanced steroid hormone production. It promotes follicular development in ovarian cells and supports spermatogenesis-related processes in testicular cells. The dual-hormone activity of HMG results in coordinated regulation of reproductive signaling pathways. No significant cytotoxicity is observed at commonly used experimental concentrations. [1]
Synonyms
Human Menopausal Gonadotropin
Chemical Properties
Molecular Weight
Not precisely defined (mixture of glycoprotein hormones)
Formula
Not applicable (multi-component glycoprotein mixture)
Cas No.
9002-68-0
Smiles
Not applicable (protein mixture)
Relative Density.
no data available
Sequence
Contains FSH and LH glycoprotein subunits
Each hormone consists of α and β subunits
Sequence Short
Not applicable (multi-hormone mixture)
Storage & Solubility Information
Storage