HCG
Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone composed of alpha and beta subunits, primarily produced by placental trophoblastic cells. It plays a key role in regulating reproductive function by mimicking luteinizing hormone (LH) activity. HCG is widely used in research involving endocrine signaling, gonadal function, and hormone regulation, particularly in studies of steroidogenesis and reproductive physiology.
Price range: $126.00 through $224.00
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Questions
HCG Common Questions
What’s pIC50?
pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
What’s Kd?
Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
Product Introduction
Bioactivity
Description
Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone composed of alpha and beta subunits, primarily produced by placental trophoblastic cells. It plays a key role in regulating reproductive function by mimicking luteinizing hormone (LH) activity. HCG is widely used in research involving endocrine signaling, gonadal function, and hormone regulation, particularly in studies of steroidogenesis and reproductive physiology.
Targets & IC50
Targets:
Luteinizing Hormone/Chorionic Gonadotropin Receptor (LHCGR)
cAMP Signaling Pathway
Steroidogenesis Pathway
IC50:
Not applicable (HCG is a hormone agonist, not an inhibitory compound)
In vitro
METHODS: Leydig cells and ovarian granulosa cells were treated with HCG (0–100 IU/mL) for 24–72 hours. Hormone production, receptor activation, and downstream signaling were evaluated using ELISA assays, cAMP measurements, and Western blot analysis.
RESULTS: HCG stimulates steroid hormone production by activating the LHCGR receptor and increasing intracellular cAMP levels. It enhances testosterone synthesis in Leydig cells and supports estrogen production in ovarian cells. HCG mimics LH activity, leading to activation of steroidogenic enzymes and endocrine signaling pathways. No significant cytotoxicity is observed at commonly used experimental concentrations. [1]
Synonyms
Human Chorionic Gonadotropin
Chemical Properties
Molecular Weight
36,700 Da
Formula
Not precisely defined (glycoprotein with variable glycosylation)
Cas No.
9002-61-3
Smiles
Not applicable (protein hormone)
Relative Density.
no data available
Sequence
HCG consists of two subunits:
Alpha subunit (~92 aa)
Beta subunit (~145 aa)
Sequence Short
237 aa total
Storage & Solubility Information
Storage