Kisspeptin-10
Price range: $91.00 through $154.00
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Questions
Kisspeptin-10 Common Questions
What’s pIC50?
pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
What’s ED50?
Product Introduction
Bioactivity
Description
Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression
In vitro
KP-10-treatment significantly increased the expression of osteogenic genes, including mRNA and protein levels of BMP2, in C3H10T1/2 cells.?Moreover, KP-10 induced BMP2-luc activity and increased phosphorylation of Smad1/5/9.?In addition, NFATc4 specifically mediated KP-10-induced BMP2 gene expression.?However, KP-10 treatment did not induce expression of the BMP2 and Runx2 genes in GPR54-/- cells.?To examine whether KP-10 induced secretion of BMP2 to the culture medium, we used the conditioned-medium (C.M) of KP-10 treated medium on C3H10T1/2 cells.?Dlx5 and Runx2 expressions were higher in GPR54-/- cells treated with C.M than in those treated with KP-10[1].
Chemical Properties
Molecular Weight
1416.46
Formula
C63H83N17O14.C2HF3O2
Smiles
CC([H])(C[C@](N=C(C/N=C([C@](CC1=CC=CC=C1)(N=C([C@](CO)(N=C([C@](CC(O)=N)(N=C([C@](CC2=CNC3=CC=CC=C23)(N=C([C@](CC(O)=N)(N=C([C@]([H])(CC4=CC=C(C=C4)O)N)O)[H])O)[H])O)[H])O)[H])O)[H])\O)O)(C(O)=N[C@@](CCCNC(N)=N)(C(O)=N[C@@](CC5=CC=CC=C5)(C(O)=N)[H])[H])[H])C.O=C(O)C(F)(F)F
Relative Density.
1.31g/cm3
Sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Sequence Short
YNWNSFGLRF
Storage & Solubility Information
Storage
Formula