DSIP
Price range: $98.00 through $392.00
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Questions
DSIP Common Questions
What’s pIC50?
pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
What’s Kd?
Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
Product Introduction
Bioactivity
Description
δ-Sleep Inducing Peptide (DSIP) is a neuropeptide exhibiting antioxidant and anxiolytic properties.
In vitro
Delta-Sleep Inducing Peptide(DSIP) and DSIP-12 significantly (*P<0.05 and **P<0.01) increased in delta and theta frequency bands and decreased the incidence, mean seizure grade and duration of metaphit convulsions. Suggest that DSIP and DSIP-12 may be considered as potential antiepileptics in the animal model[1].
Animal Research
The rats divided in four groups received (i.p.): saline; metaphit; metaphit+DSIP; and metaphit+DSIP-12, respectively. Metaphit-treated animals displaying seizure in eight previous tests received DSIP or DSIP-12 and afterwards audiogenic stimuli were applied at hourly intervals for the next 30 h. The animals were exposed to sound stimulation 60 min after metaphit administration and further on at hourly intervals. Incidence and severity of seizures were behaviorally analyzed. Selected EEGs and power spectra were recorded and analyzed[1].
Synonyms
DSIP, Delta-Sleep Inducing Peptide
Chemical Properties
Molecular Weight
848.81
Formula
C35H48N10O15
Cas No.
62568-57-4
Smiles
CC(NC(=O)C(N)Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NCC(=O)NC(CC(O)=O)C(=O)NC(C)C(=O)NC(CO)C(=O)NCC(=O)NC(CCC(O)=O)C(O)=O
Relative Density.
1.458 g/cm3
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Sequence Short
WAGGDASGE
Storage & Solubility Information
Storage
Formula
References
- 1.Stanojlovi O P , Ivanovi D P , Mirkovi S D , et al. Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats[J]. Seizure European Journal of Epilepsy, 2005, 14(4):0-247.
- 2.Monnier M , Dudler L , G?Chter R , et al. The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide[J]. 1977, 33(4):548-552.