GHRP-6
GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide belonging to the growth hormone secretagogue (GHS) family. It functions as an agonist of the ghrelin receptor and stimulates the release of growth hormone (GH) from the anterior pituitary. GHRP-6 is widely used in research related to endocrine regulation, appetite signaling, and metabolic processes, and is known for its strong GH-releasing activity and orexigenic (appetite-stimulating) effects.
Price range: $42.00 through $70.00
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Questions
GHRP-6 Common Questions
What’s pIC50?
pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
What’s Kd?
Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
Product Introduction
Bioactivity
Description
GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide belonging to the growth hormone secretagogue (GHS) family. It functions as an agonist of the ghrelin receptor and stimulates the release of growth hormone (GH) from the anterior pituitary. GHRP-6 is widely used in research related to endocrine regulation, appetite signaling, and metabolic processes, and is known for its strong GH-releasing activity and orexigenic (appetite-stimulating) effects.
Targets & IC50
Targets:
Growth Hormone Secretagogue Receptor (GHSR)
GH/IGF-1 Axis
Calcium Signaling Pathway
IC50:
Not applicable (GHRP-6 is a receptor agonist peptide, not an inhibitory compound)
In vitro
METHODS: Rat pituitary cells and GH-secreting cell lines were treated with GHRP-6 (0–100 nM) for 1–24 hours. Growth hormone secretion and intracellular signaling were evaluated using ELISA assays and calcium flux measurements.
RESULTS: GHRP-6 stimulates growth hormone release in a dose-dependent manner via activation of the ghrelin receptor (GHSR). It enhances intracellular calcium signaling and promotes pulsatile GH secretion. Compared to other GHRPs, GHRP-6 exhibits strong GH-releasing potency and is associated with increased appetite-related signaling. No significant cytotoxicity is observed at commonly used experimental concentrations. [1]
Synonyms
Growth Hormone Releasing Peptide-6
Chemical Properties
Molecular Weight
873.0 Da
Formula
C₄₆H₅₆N₁₂O₆ (approximate)
Cas No.
87616-84-0
Smiles
Not applicable (peptide)
Relative Density.
no data available
Sequence
His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
Sequence Short
6 aa
Storage & Solubility Information
Storage