GHRP-2
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide belonging to the growth hormone secretagogue (GHS) class. It acts as a potent agonist of the ghrelin receptor, stimulating the release of growth hormone (GH) from the anterior pituitary. GHRP-2 is widely used in research involving endocrine regulation, GH secretion, appetite signaling, and metabolic processes.
Price range: $42.00 through $98.00
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Questions
GHRP-2 Common Questions
What’s pIC50?
pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
What’s Kd?
Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
Product Introduction
Bioactivity
Description
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide belonging to the growth hormone secretagogue (GHS) class. It acts as a potent agonist of the ghrelin receptor, stimulating the release of growth hormone (GH) from the anterior pituitary. GHRP-2 is widely used in research involving endocrine regulation, GH secretion, appetite signaling, and metabolic processes.
Targets & IC50
Targets:
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Growth Hormone Secretagogue Receptor (GHSR)
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GH/IGF-1 Axis
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Calcium Signaling Pathway
IC50:
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Not applicable (GHRP-2 is a receptor agonist peptide, not an inhibitory compound)
In vitro
METHODS: Rat pituitary cells and GH-secreting cell lines were treated with GHRP-2 (0–100 nM) for 1–24 hours. Growth hormone secretion and intracellular signaling were evaluated using ELISA assays and calcium flux measurements.
RESULTS: GHRP-2 stimulates growth hormone release in a dose-dependent manner via activation of the ghrelin receptor (GHSR). It enhances intracellular calcium signaling and promotes pulsatile GH secretion. Compared to other GHRPs, GHRP-2 demonstrates strong potency in GH stimulation, although it may also influence additional endocrine pathways. No significant cytotoxicity is observed within commonly used experimental concentrations. [1]
Synonyms
Growth Hormone Releasing Peptide-2
Chemical Properties
Molecular Weight
817.0 Da
Formula
C₄₅H₅₅N₉O₆ (approximate)
Cas No.
158861-67-7
Smiles
Not applicable (peptide)
Relative Density.
no data available
Sequence
D-Ala-D-β-Nal-Ala-Trp-D-Phe-Lys-NH₂
Sequence Short
6 aa
Storage & Solubility Information
Storage