L-carnitine
$70.00
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Questions
L-carnitine Common Questions
What’s pIC50?
pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
What’s IC50?
Half-maximal inhibitory concentration (IC50) refers to the concentration of the inhibitor which is required to inhibit a given biological or biochemical function by half.
Product Introduction
Bioactivity
Description
L-Carnitine (L(-)-Carnitine) is an amino acid derivative. L-Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy production. Fatty acids are utilized as an energy substrate in all tissues except the brain.
Targets & IC50
Targets:
Carnitine Palmitoyltransferase I (CPT1)
Carnitine Palmitoyltransferase II (CPT2)
Carnitine–Acylcarnitine Translocase (CACT)
Fatty Acid β-oxidation Pathway
IC50:
Not applicable
(L-Carnitine is not an inhibitor but a carrier molecule involved in fatty acid transport)
In vitro
METHODS: HepG2 hepatocytes, C2C12 myoblasts, and 3T3-L1 adipocytes were treated with L-Carnitine (0–5 mM) for 24–72 hours. Fatty acid oxidation, mitochondrial function, and metabolic enzyme expression were evaluated using enzymatic assays, oxygen consumption rate (OCR) analysis, and Western blot detection of lipid metabolism-related proteins.
RESULTS: L-Carnitine enhances mitochondrial fatty acid transport and significantly increases β-oxidation activity. It promotes the conversion of long-chain fatty acids into acylcarnitines, facilitating their transport into mitochondria for energy production. Additionally, L-Carnitine improves mitochondrial respiration and metabolic efficiency, while reducing lipid accumulation in adipocytes. No significant cytotoxicity is observed within commonly used experimental concentration ranges. [1]
Synonyms
Levocarnitine, L(-)-Carnitine
Chemical Properties
Molecular Weight
161.20
Formula
C7H15NO3
Cas No.
541-15-1
Smiles
C[N+](C)(C)C[C@@H](O)CC([O-])=O
Relative Density.
0.64 g/cm3
Sequence
no data available
Sequence Short
no data available
Storage & Solubility Information
Storage
Formula
Solution Preparation Table
DMSO/H2O/Ethanol
|
1mg |
5mg |
10mg |
50mg |
|
|---|---|---|---|---|
|
1 mM |
6.2035 mL |
31.0174 mL |
62.0347 mL |
310.1737 mL |
|
5 mM |
1.2407 mL |
6.2035 mL |
12.4069 mL |
62.0347 mL |
|
10 mM |
0.6203 mL |
3.1017 mL |
3.1017 mL |
31.0174 mL |
|
20 mM |
0.3102 mL |
1.5509 mL |
3.1017 mL |
15.5087 mL |
H2O/Ethanol
|
1mg |
5mg |
10mg |
50mg |
|
|---|---|---|---|---|
|
50 mM |
0.1241 mL |
0.6203 mL |
1.2407 mL |
6.2035 mL |
|
100 mM |
0.0620 mL |
0.3102 mL |
0.6203 mL |
3.1017 mL |
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.