SLU-PP-332
$196.00
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Questions
SLU-PP-332 Common Questions
How long does sonication usually take?
The sonication time depends on the amount and concentration of the substance
Does the product need to be protected from light?
Generally, for molecules that require light-protected storage, we will ship them in amber glass bottles.
Product Introduction
Bioactivity
Description
SLU-PP-332 is a pan-estrogen receptor-related receptor (ERR) agonist with high affinity for ERRα, ERRβ, and ERRγ, exhibiting EC50 values of 98, 230, and 430 nM, respectively. SLU-PP-332 enhances mitochondrial function and cellular respiration, increases type IIa oxidized skeletal muscle fibers, and enhances exercise tolerance in skeletal muscle cell lines. It has potential applications in the study of metabolic diseases, improvement of muscle function, and amelioration of metabolic disorders and aging.
Targets & IC50
ERRα:98 nM (EC50), ERRγ:430 nM (EC50), ERRβ:230 nM (EC50)
In vitro
METHODS: C2C12 myoblasts and primary skeletal muscle cell models were treated with SLU-PP-332 (0–10 μM) for 24–72 hours. Gene and protein expression related to oxidative metabolism were evaluated using qPCR and Western blot analysis, along with mitochondrial function assays.
RESULTS: SLU-PP-332 activates estrogen-related receptor (ERR) signaling in a dose-dependent manner, leading to increased expression of genes associated with mitochondrial biogenesis and oxidative phosphorylation. It enhances metabolic activity and promotes a shift toward oxidative muscle fiber characteristics. No significant cytotoxicity is observed within commonly used experimental concentration ranges. [1]
Synonyms
Estrogen-related receptor agonist SLU-PP-332
Chemical Properties
Molecular Weight
290.32
Formula
C18H14N2O2
Cas No.
303760-60-3
Smiles
C(=NNC(=O)C1=CC=C(O)C=C1)C2=CC3=C(C=C2)C=CC=C3
Relative Density.
1.20 g/cm3 (Predicted)
Storage & Solubility Information
Storage
Formula
Solution Preparation Table
DMSO
|
1mg |
5mg |
10mg |
50mg |
|
|---|---|---|---|---|
|
1 mM |
3.4445 mL |
17.2224 mL |
34.4448 mL |
172.2238 mL |
|
5 mM |
0.6889 mL |
3.4445 mL |
6.8890 mL |
34.4448 mL |
|
10 mM |
0.3444 mL |
1.7222 mL |
3.4445 mL |
17.2224 mL |
|
20 mM |
0.1722 mL |
0.8611 mL |
1.7222 mL |
8.6112 mL |
|
50 mM |
0.0689 mL |
0.3444 mL |
0.6889 mL |
3.4445 mL |
|
100 mM |
0.0344 mL |
0.1722 mL |
0.3444 mL |
1.7222 mL |
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.