Cagrilintide
Cagrilintide Price range: $154.00 through $308.00
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AOD 9604
AOD 9604 Price range: $77.00 through $252.00

Cagrilintide + Semaglutide

Catalog No.

T76262+T19850

Purity:

99.95%+99.78%

⭐️⭐️⭐️⭐️⭐️

HOT
Cagrilintide is a long-acting amylin analogue acting as a dual agonist of the amylin receptor and calcitonin receptor, reducing body weight and food intake for obesity research.
Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist(EC50 of 6.2 pM in a reporter assay using BHK cells expressing the human receptor).
Cagrilintide + Semaglutide - Image 1
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$252.00

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Common Questions

What’s pIC50?

pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).

What’s Kd?

Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.

Product Introduction

Bioactivity

Description

Cagrilintide is a long-acting amylin analogue acting as a dual agonist of the amylin receptor and calcitonin receptor, reducing body weight and food intake for obesity research.

Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist(EC50 of 6.2 pM in a reporter assay using BHK cells expressing the human receptor).

Targets & IC50

Semaglutide: albumin:27 µM, GLP1 receptor:6.2 pM (EC50)

In vitro

Cagrilintide (compound 23) (0.1, 1, 3, 10, and 30 nmol/kg, subcutaneous injection) reduced food intake in rats [2]. Cagrilintide (10 nmol/kg, administered intravenously or subcutaneously) exhibited favorable pharmacokinetic parameters [2].

Chemical Properties

Molecular Weight

Cagrilintide: 4409.01 Semaglutide: 4114

Formula

Cagrilintide: C194H312N54O59S2

Semaglutide: C187H291N45O59

Cas No.

Cagrilintide: 1415456-99-3 Semaglutide: 910463-68-2

Smiles

Semaglutide: CC[C@@H]([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(C(C)(NC([C@@H](N)CC1=CN=CN1)=O)C)=O)CCC(O)=O)=O)=O)[C@H](O)C)=O)CC2=CC=CC=C2)=O)[C@H](O)C)=O)CO)=O)CC(O)=O)=O)C(C)C)=O)CO)=O)CO)=O)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@@H](NC(CCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)=O)=O)=O)CCC(O)=O)=O)CC4=CC=CC=C4)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CC(C)C)=O)CC5=CNC6=CC=CC=C65)=O)C)=O)C

Relative Density.

no data available

Sequence

Cagrilintide: {Eicosanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH2 (Disulfide bridge:Cys3-Cys8)

Semaglutide: His-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-{C18 diacid-γ-Glu-(AEEA)2-Lys}-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly

Sequence Short

Cagrilintide: {Eicosanedioic acid-γ-Glu}-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP (Disulfide bridge:Cys3-Cys8)

Semaglutide: {Aib}-EGTFTSDVSSYLEGQAA-{C18 diacid-γ-Glu-(AEEA)2-Lys}-​​​EFIAWLVRGRG

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.
Actual storage temperature shall be subject to the COA.

Formula

Cagrilintide
H2O: 80 mg/mL (18.14 mM), Sonication is recommended.🏅
 
Semaglutide
H2O: 10 mg/mL (2.43 mM), when pH is adjusted to 14 with NaOH. Sonication and heating are recommended. 🏅
H2O: insoluble 🏅
DMSO: 50 mg/mL (12.15 mM), Sonication is recommended. 🏅
H2O: 5 mg/mL (1.22 mM), when pH is adjusted to 1 with HCl. Sonication and heating are recommended. 🏅

Solution Preparation Table

H2O

1mg

5mg

10mg

1 mM

0.2268 mL

1.1340 mL

2.2681 mL

11.3404 mL

5 mM

0.0454 mL

0.2268 mL

0.4536 mL

2.2681 mL

10 mM

0.0227 mL

0.1134 mL

0.2268 mL

1.1340 mL

H2O/H2O/DMSO

1mg

5mg

10mg

50mg

1 mM

0.2431 mL

1.2154 mL

2.4307 mL

12.1536 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

References